I can confirm this with v4.0.2.7. It needs to be noted that the USA release of ME2 on DVD does not employ SecuROM. The protection is, in fact, a disc check as was the case with Dragon Age: Origins. Oddly, my Dragon Age: Origins profile didn't break. I tried creating a brand new ME2 profile using the Automatic setting, as I have always done with this disc check games, and it resulted in the same message when trying to launch the resulting profile after an apparent successful creation.
I'm running Windows 7 Ultimate x64.