Read if you're running Vista

[DrinkLyeAndDie]

With a small amount of looking you'll find a file named Install_Important_Vista.txt in the install directory of the Slysoft release of GameJackal Pro.

Windows Vista Support.

There are a few things to note when running Game Jackal under Windows Vista.
The first being that, although Game Jackal is compatible with Windows Vista, most games currently on the market are not fully compatible. This can cause issues when creating and using Game Jackal profiles.
If you experience problems under Vista, we recommend that you try the following (in the order listed).
1) Make sure the game has been patched with the latest updated available.
2) Run Game Jackal as administrator. To do this right-click the Game Jackal icon, select "Properties", followed by the "Compatibilty" tab. Then check "Run this program as administrator".
3) If you still experiencing problems, turning off UAC will fix most issues (we only recommend this option for experienced users).

 

[Webslinger]

Also, ensure you have the Vista hotfix installed:

Vista hotfix (click the link)