I have been having a problem for a while with CloneDVD2/AnyDVD on Windows Vista x64. I can't remember when the issue started, but it still occurs with 18.104.22.168 and 22.214.171.124. Basically Clone will work normally for a few disks and then suddenly when I insert a new disk, Clone will issue the attached error when ever I try to start I have two DVD-R drives and the problem will happen in either one. Sometimes if I insert a new disk, it will start working, sometimes not. If I reboot my machine the problem disk will work normally.