I was having a similar problem. I'm running Windows Vista Ultimate (32-Bit). I recently upgraded from XP. In XP, it worked great. In Vista, CloneDVD, no-workee so good.
I had AnyDVD running and CloneDVD and when CloneDVD went to start the scan on the Audio and Subtitle settings, the whole pc froze. I had to cold boot the pc to recovery.
In the event viewer I found this:
"The program CloneDVD2.exe version 22.214.171.124 stopped interacting with Windows and was closed. To see if more information about the problem is available, check the problem history in the Problem Reports and Solutions control panel. Process ID: c44 Start Time: 01c747ac818c433c Termination Time: 60000"
But a few entries earlier I found this in the event viewer"
"A thread in process C:\Program Files\McAfee\VirusScan Enterprise\Mcshield.exe took longer than 90000 ms to complete a request.
The process will be terminated. Thread id : 3372 (0xd2c)
Thread address : 0x77520F34
Thread message :
Build VSCORE.126.96.36.199 / 5100.194
Object being scanned = \Device\CdRom1\VIDEO_TS\VIDEO_TS.VOB
by C:\Program Files\Elaborate Bytes\CloneDVD2\CloneDVD2.exe"
By adjusting my Virus scan On-Access-Scan to exclude my DVD drives, CloneDVD work perfectly again.
Maybe your settings are similiar?