At least, in any case you should use CloneDVD when the copy to ISO with AnyDVD alone (<=without CloneDVD) makes issues, and you still need time to test this, too when copy finshed.
I've bought a few CloneDVD licenses, to support the CLoneDVD project, too. I know it might appear strange, I've used CloneDVD2 only in rare cases to make ISO from DVD.
I've used AnyDVD alone or together with ImgBurn for DVDs copied to ISO, so far no real bad side effects.
The reason I use AnyDVD mostly alone, because read s.th. about bug with CloneDVD2 in the past, but most probably alreday resolved of course. I want to minimice the risk by avoiding to use an additional 2nd application together.
But I'd guess maybe some old bugs resolved in CloneDVD2 happened because removing some titles/chapters, some language/s or advertisment trailers from the DVD.
In any case a "full" ISO dump with CloneDVD will have fewest risk, compared to removing some of those parts on DVD.
And if the DVD has structural copy protection, there could be issues when using AnyDVD alone (or ImgBurn+AnyDVD) - CloneDVD2 removes that kind of protection.
Though tested just 3-4 DVD-discs with structural copy protection without CloneDVD, so far using AnyDVD or AnyDVD+ImgBurn worked OK on computer.
Can't say what would be the result with standalone players.
Still DVD-ROMs have that structural thing not removed, too, and so far didn't hear about issues on players.
If you want to process movie further you will have to rerip the ISO to remove structural copy protection anyway, for that reason it's most probably smarter using CloneDVD2 in the first place.